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For research use only. Not for human or veterinary use.MOTS-c. For research use only. Not for human or veterinary use.

MOTS-c research peptide

$59.00 – $177.00

For research use only. Not for human or veterinary use.

  • ≥98% by HPLC (lot-specific)
  • Canada fulfilment

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Third-party lab verified

HPLC + MS

Independently tested for identity and purity

Batch
MOTS-080426
Tested
August 04, 2026
Purity
99.1%

Tested by Testides

MOTS-c

$118.00

Product description

MOTS-c research peptide is supplied to qualified Canadian institutions as a characterized laboratory material for in vitro mitochondrial-peptide and metabolic-signalling studies. The compound is a 16-residue mitochondrial-derived peptide encoded in the 12S rRNA region of mitochondrial DNA (sequence MRWQEMGYIFYPRKLR).

In vitro, MOTS-c is used to probe folate–methionine-cycle and AMPK-pathway readouts and to study stress-dependent nuclear translocation reported for this open reading frame. Typical designs apply the peptide to cultured cells or isolated metabolic assays and record AMPK-proximal phosphorylation, one-carbon-cycle metabolites, or nuclear-localization markers. This listing describes biochemical use in experimental systems only.

The material is offered as a lyophilized vial. Identity data (CAS 1627580-64-6, formula C101H152N28O22S2, molecular weight 2174.6 g/mol, PubChem CID 146675088) are listed on the specification table. Store lyophilized at −20 °C, protected from light, and handle under the receiving institution's chemical-hygiene plan.

Lots are sourced from a GMP-aligned peptide manufacturing partner and released against the stated HPLC purity for that lot (≥98% by HPLC, lot-specific). Identity, chromatographic purity, and related analytical results are documented on the lot certificate of analysis (COA). Retain the COA with the inventory record.

This listing is a research-use-only peptide offered to qualified Canadian institutions for in vitro and laboratory use. Purchasing access is limited to verified Canadian research institutions; individual consumer accounts are not accepted. It is not for human or veterinary use, is not intended for diagnostic procedures, and has not been evaluated or authorized by Health Canada as a drug, diagnostic, or medical product.

Material specifications

Fields a receiving desk can paste into an order record.

SKU
NL-MOTS-10
Pack
10 mg lyophilized vial
Purity
≥98% by HPLC (lot-specific)
CAS
1627580-64-6
Molecular formula
C101H152N28O22S2
Molecular weight
2174.6 g/mol
Sequence
MRWQEMGYIFYPRKLR
PubChem CID
146675088

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Details+ Add

Common questions

It is encoded within the mitochondrial genome, in an open reading frame located inside the 12S ribosomal RNA gene, rather than in nuclear DNA. That places it in a small class of mitochondrial-derived peptides that also includes humanin.
No, and the distinction matters. Lee and colleagues reported that MOTS-c acts on the folate-methionine cycle; inhibiting that cycle causes AICAR to accumulate, and AICAR is an endogenous AMPK activator. AMPK activation is therefore a downstream metabolic consequence rather than a direct action on the kinase.
Retrograde signalling refers to information travelling from mitochondria to the nucleus, the reverse of the usual direction of organelle regulation. MOTS-c has been reported to move into the nucleus under metabolic stress and influence transcription of nuclear genes, which is why it is proposed as a mediator of that pathway.
Not as an administered compound in any published controlled trial. The human literature consists of observational measurements of endogenous levels around exercise and a genetic association study linking a sequence variant to longevity in a Japanese cohort. All functional evidence comes from cells and rodents.
It is a single-population finding, and the authors themselves framed it as a question. Fuku and colleagues reported an association between a MOTS-c sequence variant and exceptional longevity in a Japanese cohort, tied to a particular mitochondrial haplogroup. Associations of this type have historically been difficult to replicate across ancestries.
MRWQEMGYIFYPRKLR - sixteen residues, with a molecular weight of about 2,175 g/mol. It contains no non-standard amino acids or chemical modifications; its distinguishing feature is the location of its coding sequence, not its chemistry.