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For research use only. Not for human or veterinary use.NAD+. For research use only. Not for human or veterinary use.

NAD+ research cofactor

$128.00

For research use only. Not for human or veterinary use.

  • ≥98% by HPLC (lot-specific)
  • Canada fulfilment

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HPLC + MS

Independently tested for identity and purity

Batch
NAD-081526
Tested
August 15, 2026
Purity
99.8%

Tested by Testides

NAD+

$128.00

Product description

NAD+ research material is supplied to qualified Canadian institutions as a characterized laboratory cofactor for in vitro enzymology, redox-cycling assays, and analytical standards. The compound is the oxidized form of nicotinamide adenine dinucleotide (β-NAD), a dinucleotide central to hydride-transfer reactions.

In vitro, NAD+ accepts electrons from dehydrogenases to form NADH and is a consumed substrate for sirtuins, poly(ADP-ribose) polymerases, and CD38. Experimental designs typically fix NAD+ as a stoichiometric cofactor, a kinetic substrate, or a calibration standard when measuring NAD+-dependent enzymes, PARP activity, or NAD+/NADH ratios in lysates and purified systems. This listing describes cofactor chemistry in experimental systems only.

The material is offered lyophilized. Identity data (CAS 53-84-9, formula C21H27N7O14P2, molecular weight 663.4 g/mol, PubChem CID 5892) are listed on the specification table. The solid is hygroscopic: equilibrate the closed vial to room temperature before opening, store at −20 °C protected from light and moisture, and handle under the receiving institution's chemical-hygiene plan.

Lots are sourced from a GMP-aligned manufacturing partner and released against the stated HPLC purity for that lot (≥98% by HPLC, lot-specific). Identity, chromatographic purity, and related analytical results are documented on the lot certificate of analysis (COA). Retain the COA with the inventory record.

This listing is research-use-only material offered to qualified Canadian institutions for in vitro and laboratory use. Purchasing access is limited to verified Canadian research institutions; individual consumer accounts are not accepted. It is not for human or veterinary use, is not intended for diagnostic procedures, and has not been evaluated or authorized by Health Canada as a drug, diagnostic, or medical product.

Material specifications

Fields a receiving desk can paste into an order record.

SKU
NL-NAD-500
Pack
500 mg lyophilized vial
Purity
≥98% by HPLC (lot-specific)
CAS
53-84-9
Molecular formula
C21H27N7O14P2
Molecular weight
663.4 g/mol
PubChem CID
5892
For research use only. Not for human or veterinary use.Bacteriostatic Water. For research use only. Not for human or veterinary use.USP GradeCOA

Bacteriostatic Water

For research use only. Not for human or veterinary use.

Laboratory Reagents

$24.00

For research use only. Not for human or veterinary use.Glutathione. For research use only. Not for human or veterinary use.99.7%COA

Glutathione

For research use only. Not for human or veterinary use.

Laboratory Reagents

$86.00

Common questions

They are the oxidised and reduced forms of the same cofactor. NAD+ accepts a hydride ion at carbon 4 of its nicotinamide ring to become NADH, and NADH gives it back to become NAD+ again. The ratio between them reflects cellular metabolic state.
Not readily. NAD+ is a large, negatively charged dinucleotide with no established plasma-membrane transporter in mammalian cells. Extracellular NAD+ is generally degraded by surface enzymes such as CD38, CD73 and ENPP family members into smaller precursors that can be transported.
Nicotinamide riboside and nicotinamide mononucleotide are biosynthetic precursors, not NAD+ itself. NR is converted to NMN by NR kinases and NMN to NAD+ by NMNAT enzymes. Most human interventional data concern these precursors rather than NAD+.
Sirtuins consume it during deacylation, PARP enzymes consume it in bulk when building poly(ADP-ribose) during the DNA damage response, and the surface glycohydrolase CD38 degrades it to ADP-ribose and cyclic ADP-ribose. All three cleave the cofactor rather than recycling it.
It is the route that recovers NAD+ from the nicotinamide released by consuming enzymes. NAMPT converts nicotinamide to NMN, and NMNAT enzymes convert NMN to NAD+. NAMPT is rate-limiting, and this pathway supplies most of the mammalian NAD+ pool.
Not established. Human trials of precursors have shown that circulating NAD+ and related metabolites can be raised, but adequately powered randomised trials with hard clinical endpoints are largely absent. Much of the outcome evidence cited in this area is preclinical.