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For research use only. Not for human or veterinary use.KPV. For research use only. Not for human or veterinary use.

KPV research peptide

$36.00 – $108.00

For research use only. Not for human or veterinary use.

  • ≥98% by HPLC (lot-specific)
  • Canada fulfilment

Size

Order before 14:00 ET - ships next business day.

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Third-party lab verified

HPLC + MS

Independently tested for identity and purity

Batch
KPV-072626
Tested
July 26, 2026
Purity
99.7%

Tested by Testides

KPV

$72.00

Product description

KPV research peptide is supplied to qualified Canadian institutions as a characterized laboratory material for in vitro melanocortin-fragment and NF-κB-pathway studies. The compound is the C-terminal tripeptide of α-melanocyte-stimulating hormone (residues 11–13; Lys-Pro-Val).

In vitro, KPV is used to dissect signalling attributed to the α-MSH C-terminus in cell models, including NF-κB-pathway readouts, without the pigmentary-domain pharmacology of full-length α-MSH at melanocortin receptors. Typical designs apply the tripeptide to epithelial or immune-cell cultures and record transcription-factor activity, cytokine-transcript panels, or comparisons against α-MSH and other fragments. This listing describes biochemical use in experimental systems only.

The material is offered as a lyophilized vial. Identity data (CAS 67727-97-3, formula C16H30N4O4, molecular weight 342.4 g/mol, PubChem CID 125672) are listed on the specification table. Store lyophilized at −20 °C, protected from light, and handle under the receiving institution's chemical-hygiene plan.

Lots are sourced from a GMP-aligned peptide manufacturing partner and released against the stated HPLC purity for that lot (≥98% by HPLC, lot-specific). Identity, chromatographic purity, and related analytical results are documented on the lot certificate of analysis (COA). Retain the COA with the inventory record.

This listing is a research-use-only peptide offered to qualified Canadian institutions for in vitro and laboratory use. Purchasing access is limited to verified Canadian research institutions; individual consumer accounts are not accepted. It is not for human or veterinary use, is not intended for diagnostic procedures, and has not been evaluated or authorized by Health Canada as a drug, diagnostic, or medical product.

Material specifications

Fields a receiving desk can paste into an order record.

SKU
NL-KPV-10
Pack
10 mg lyophilized vial
Purity
≥98% by HPLC (lot-specific)
CAS
67727-97-3
Molecular formula
C16H30N4O4
Molecular weight
342.4 g/mol
Sequence
KPV
PubChem CID
125672
For research use only. Not for human or veterinary use.BPC-157. For research use only. Not for human or veterinary use.99.74%COA

BPC-157

For research use only. Not for human or veterinary use.

Tissue Repair

$78.00

For research use only. Not for human or veterinary use.GHK-Cu. For research use only. Not for human or veterinary use.99.5%COA

GHK-Cu

For research use only. Not for human or veterinary use.

Tissue Repair

$84.00

For research use only. Not for human or veterinary use.TB-500. For research use only. Not for human or veterinary use.99.2%COA

TB-500

For research use only. Not for human or veterinary use.

Tissue Repair

$88.00

Common questions

KPV is the C-terminal tripeptide of α-melanocyte-stimulating hormone, occupying residues 11 to 13 of the thirteen-residue sequence SYSMEHFRWGKPV. It is often written α-MSH(11–13) in the literature.
The melanocortin pharmacophore responsible for receptor binding and pigmentation is the His-Phe-Arg-Trp motif at positions 6 to 9, which KPV does not contain. Retention of anti-inflammatory activity without that motif is the reason the fragment is studied.
Cell studies consistently report suppression of NF-κB pathway activation and reduced downstream inflammatory cytokine output. The proximal molecular target producing that effect has not been established, and work in human keratinocytes found KPV did not signal through the classical melanocortin receptor route.
PepT1 is a proton-coupled transporter that carries di- and tripeptides into epithelial cells. It is the identified uptake route for KPV in intestinal epithelium, and because colonic expression of PepT1 increases under inflammatory conditions, access to tissue varies with inflammatory state.
No published human clinical trials of KPV have been reported. The indexed evidence base consists of in vitro work in cultured epithelial, immune and keratinocyte cells, and rodent models of colitis and neurological injury.
No. KPV is not an approved drug in Canada or the United States. Reviews of α-MSH-related tripeptides describe clinical application as a future prospect rather than an achieved one.