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For research use only. Not for human or veterinary use.CJC-1295 (with DAC). For research use only. Not for human or veterinary use.

CJC-1295 (with DAC) research peptide

$112.00 – $336.00

For research use only. Not for human or veterinary use.

  • ≥98% by HPLC (lot-specific)
  • Canada fulfilment

Size

Order before 14:00 ET - ships next business day.

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Third-party lab verified

HPLC + MS

Independently tested for identity and purity

Batch
CDAC-072226
Tested
July 22, 2026
Purity
98.8%

Tested by Testides

CJC-1295 (with DAC)

$112.00

Product description

CJC-1295 (with DAC) research peptide is supplied to qualified Canadian institutions as a characterized laboratory material for in vitro GHRH-receptor and albumin-conjugation studies. The compound is a GHRH(1-29) analogue extended with a lysine-linked maleimidopropionic acid drug-affinity complex (DAC).

In vitro, the DAC moiety is designed to form a covalent adduct with serum albumin, which is why the analogue is used when an experimental design must distinguish short-window Modified GRF (1-29) occupancy from an albumin-bound species. Typical assays record GHRH-receptor activation, second-messenger readouts, or albumin-binding / conjugate-stability measurements relative to the non-DAC analogue. This listing describes receptor and bioconjugate chemistry in experimental systems only.

The material is offered as a lyophilized vial. Identity data (CAS 446262-90-4, formula C165H269N47O46, molecular weight 3647.2 g/mol, PubChem CID 91971820) are listed on the specification table. Store lyophilized at −20 °C, protected from light, and handle under the receiving institution's chemical-hygiene plan.

Lots are sourced from a GMP-aligned peptide manufacturing partner and released against the stated HPLC purity for that lot (≥98% by HPLC, lot-specific). Identity, chromatographic purity, and related analytical results are documented on the lot certificate of analysis (COA). Retain the COA with the inventory record.

This listing is a research-use-only peptide offered to qualified Canadian institutions for in vitro and laboratory use. Purchasing access is limited to verified Canadian research institutions; individual consumer accounts are not accepted. It is not for human or veterinary use, is not intended for diagnostic procedures, and has not been evaluated or authorized by Health Canada as a drug, diagnostic, or medical product.

Material specifications

Fields a receiving desk can paste into an order record.

SKU
NL-CJCD-5
Pack
5 mg lyophilized vial
Purity
≥98% by HPLC (lot-specific)
CAS
446262-90-4
Molecular formula
C165H269N47O46
Molecular weight
3647.2 g/mol
PubChem CID
91971820
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Common questions

The DAC - drug affinity complex - is a maleimidopropionic acid linker that binds covalently to a free thiol on serum albumin. With it, the analogue circulates for days as part of a roughly 66 kDa albumin adduct; without it, the bare peptide clears within minutes. Same GHRH receptor, same substituted backbone, radically different exposure duration.
Days rather than minutes. Jetté and colleagues characterised it as a long-lasting GRF analogue in rats, and Teichman and colleagues reported prolonged growth hormone and IGF-1 stimulation in healthy adults. The persistence derives from albumin's own long serum residence rather than from the peptide's intrinsic stability.
No, according to the one study that examined it. Ionescu and Frohman reported in 2006 that pulsatile secretion persisted during continuous stimulation by CJC-1295. This suggests the GHRH receptor acts as a permissive input while pituitary and somatostatin dynamics continue to generate the pulses.
No. It has one substantial published human study and no completed Phase 3 programme or approved indication in any jurisdiction. On the same receptor, tesamorelin does hold an approved label, which is the clearest illustration of how far apart the two evidence bases are.
Through Michael addition. The maleimide group is an electrophile that reacts selectively with free sulfhydryl groups, and human serum albumin presents one accessible unpaired cysteine. The reaction forms a stable covalent thioether bond, so the linkage is permanent rather than reversible.
The literature does not settle it. Pulsatility survives continuous stimulation, which weakens the main argument against long action, but the somatotroph desensitisation findings conflict between studies and the comparison of continuous against intermittent delivery has been posed as an open question since the 1980s.